The editors-in-chief are Mikhail Blagosklonny and Andrei V.
The journal was established in 2010 and is published by Impact Journals. The prognostic information provided by HOTAIRM1 was strengthened when combined with miR-196b expression. Oncotarget Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal.
Determination of HOTAIRM1 level at diagnosis provided relevant prognostic information in IR-AML and allowed refinement of risk stratification based on common molecular markers. miR-196b and HOTAIRM1 in combination as a prognostic factor can classify patients as high-, intermediate-, or low-risk (5-year OS: 24% vs 42% vs 70% P = 0.004). miR-196b is located in the HOX genomic region and has previously been reported to have an independent prognostic value in AML. Moreover, HOTAIRM1 expression was associated with a specific 33- microRNA signature that included miR-196b (P < 0.001). Interestingly, HOTAIRM1 was overexpressed in NPM1-mutated AML (P < 0.001) and within this group retained its prognostic value (OR: 2.21 P = 0.01). Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Moreover, HOTAIRM1 maintained its independent prognostic value within the favorable molecular subgroup (OR: 3.43 P = 0.009). In 215 IR-AML patients, high HOTAIRM1 expression was independently associated with shorter overall survival OR: 2.04 P = 0.001), shorter leukemia-free survival (OR: 2.56 P < 0.001) and a higher cumulative incidence of relapse (OR: 1.67 P = 0.046). The lowest expression level was observed in acute promyelocytic leukemia (P < 0.001) and the highest in t(6 9) AML (P = 0.005). We have also analyzed the prognostic value of HOTAIRM1 expression in 215 intermediate-risk AML (IR-AML) patients.
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2018 CKS protein overexpression renders tumors susceptible to a chemotherapeutic strategy that protects normal tissues. It can insert citations and references from the library directly into your manuscript and use Microsoft Word to build a bibliography. Oncotarget applies the Creative Commons Attribution 3.0 License (CC BY 3.0) to all works we publish (read the human-readable summary or the full license legal code). We have correlated HOTAIRM1 expression with a miRNA expression profile. Measuring glucocorticoid receptor expression in vivo with PET. We have examined the expression of the lncRNA HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) in 241 AML patients. In conclusion, our study demonstrated the promising value of few molecular biomarkers, especially TERT promoter mutations in predicting distant metastasis in papillary thyroid cancers, while BRAF mutations showed no association with distant metastasis.Long non-coding RNAs (lncRNAs) are deregulated in several tumors, although their role in acute myeloid leukemia (AML) is mostly unknown. BRAF mutations were not associated with an elevated risk for distant metastasis (odds ratio = 0.79 95% confidence interval = 0.54-1.16). Overall, the presence of TERT promoter (odds ratio = 5.95 95% confidence interval = 2.95-11.99), RAS mutations (odds ratio = 2.5 95% confidence interval = 1.00-6.22), and RET/PTC rearrangements (odds ratio = 1.92 95% confidence interval = 1.03-3.56) were found to be associated with a significantly increased risk for distant metastasis.
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In total, 42 studies with 11,109 papillary thyroid cancers were included for meta-analyses. Low doses of free DOX were compared to equivalent DOX loaded nanogels in a. Oncotarget citation style guide with bibliography and in-text referencing examples: Journal articles Books Book chapters Reports Web pages. Four electronic databases including PubMed, Web of Science, Scopus, and Virtual Health Library were searched, and odds ratio and its 95% confidence interval concerning the association of BRAF, RAS, and TERT promoter mutations and RET/PTC rearrangements with distant metastasis were calculated using random-effects model. We performed a meta-analysis to investigate the role of molecular markers as predictors for distant metastasis in papillary thyroid cancer. Background: Gefitinib, erlotinib and afatinib provide remarkable response rates and progression-free survival compared to platinum-based chemotherapy in patients with non-small cell lung cancer harboring epidermal growth factor receptor-activating mutations, and are therefore standard first-line treatment in these patients. The presence of distant metastasis is associated with an adverse outcome in papillary thyroid cancer. Oncotarget’s Volume 12, Issue 24 New Publications Listen to an audio version of this post Cover (Research Paper): CCL20 induces colorectal cancer neoplastic epithelial cell proliferation, migration, and further CCL20 production through autocrine HGF-c-Met and MSP-MSPR signaling pathways.
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